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Advancing Multisite Clinical Research Through Integrated Clinical and Data Coordination

The Multisite Trial Coordinating Center (MTCC) integrates a Trial Coordinating Center (TCC) and a Data Coordinating Center (DCC) to advance excellence in multisite clinical research. By bringing together complementary expertise in clinical coordination, methodology, operations and data coordination, the MTCC partners with investigators to design, coordinate, conduct and disseminate innovative, rigorous and impactful multicenter studies.

Graphic for MTCC Clinical Study Support life cycle nad this image establishes the following: 1.Proposal DevelopmentFunding ApplicationRegulatory Risk Review, 2. IntakeOperational ReviewsData Management StrategyRegulatory Strategy Checks, 3. Protocol DevelopmentStatistical ConsiderationsRandomization and Blinding, 4.  ImplementationCase Report Forms (CRFs)Data Standards and DerivationsDSMB Charter, 5. Pre-LaunchRegulatory Submission and ApprovalDetailed DMP, DQP, 6. LaunchSAP and TFL ShellsDry-Run and ReadinessDSMB Open Session Report, 7. Report and Close-OutSAP and Database LockFinal ReportsRegulatory SubmissionSupport

Mission

To provide end to end study support to conduct multisite trials in a manner that is scientifically rigorous, operationally efficient and compliant.

Who We Are

The Ohio State University Multisite Trials Coordinating Center (MTCC) brings together nationally recognized expertise across the full lifecycle of multisite clinical research. Our multidisciplinary leadership and integrated teams provide end‑to‑end coordination for complex studies, ensuring scientific rigor, operational efficiency, regulatory compliance and high‑quality data.

MTCC experts have decades of experience designing and leading multisite clinical trials, including randomized controlled trials, pragmatic trials, observational studies and implementation studies, across academic, federally funded and industry‑sponsored settings. Our collective experience spans therapeutic areas such as cardiovascular disease, cancer, pancreatic disease, genomic medicine, pediatrics, mental health and rare diseases, as well as trials involving vulnerable populations and multinational sites.

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